NAT10-mediated ac4C modification of BMP6 regulates osteogenic differentiation of bone marrow-derived mesenchymal stem cells in the pathogenesis of Adolescent idiopathic scoliosis.
BACKGROUND Adolescent idiopathic scoliosis (AIS) is a three-dimensional spinal deformity. Bone morphogenetic protein 6 (BMP6) drives osteogenesis; this study probes BMP6 mechanism and its potential role in the impaired osteogenic differentiation of AIS-BMSCs. METHODS AIS-BMSCs were isolated and their surface markers...