Structure-informed characterization of a TLR2-binding scFv reveals a CDR-centered recognition model.
Toll-like receptor 2 (TLR2) is a cell-surface pattern-recognition receptor that contributes to inflammatory signaling and represents an accessible target for extracellular protein binders. Here, we integrated phage-display screening, biophysical characterization, comparative protein-protein docking, in silico perturbat...