Author

Jun-Ru Chen

2 papers indexed here

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Open access Sep 2026

S1P-TREM2 axis protects immunosuppressive neutrophils from ferroptosis to promote tumour progression in hepatocellular carcinoma.

BACKGROUND Neutrophils are increasingly recognised as immunosuppressive drivers of hepatocellular carcinoma (HCC), yet their persistence in the oxidative, lipid-rich tumour microenvironment remains poorly understood. OBJECTIVE To elucidate the metabolic and molecular programmes that enable tumour-associated neutrophi...

Jun Ma, Tong Wu, Di-Yu Chen et al. · Gut · 0 citations

Open access Aug 2026

UBE2S Promotes KIRC Progression by Regulating CDC20 Expression and Suppressing FDX1‐Mediated Cuproptosis, While Promoting M2 Macrophage Polarization

Functional experiments demonstrate that UBE2S promotes KIRC cell proliferation and migration while inhibiting apoptosis and drives KIRC progression by regulating CDC20 expression and suppressing FDX1‐mediated cuproptosis, thereby promoting tumor‐associated macrophage polarization.

Jun-Ru Chen, Yu Gao, Yue-Long Feng et al. · Molecular Carcinogenesis · 0 citations