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Author

Jun R. Huh

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2 papers indexed here

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Open access Sep 2026

GPCR antagonism via rewiring of receptor trafficking and degradation

G protein–coupled receptors (GPCRs) represent one of the most important yet incompletely addressed classes of therapeutic targets1. Here, we report a novel strategy for functional GPCR antagonism via bispecific antibody-mediated endocytosis and lysosomal degradation. GPCR-TfR1 targeting chimeras (GTACs) achieve potent...

Kaitlin Rhee, L. Shue, Akimasa Adachi et al. · 1 citation
#protein folding Open access Aug 2026

Engineering Piezo1‐Mediated Calcium Signalling for Enhanced Extracellular Vesicle Biogenesis and Cargo Loading

The use of the mechanosensitive ion channel Piezo1 as a robust regulator of EV biogenesis is exploited and mechanotransduction is identified as a key regulator of sEV biogenesis, underscoring the need for precise temporal control for the rational engineering of next-generation sEV therapeutics.

N. Saleh, Rozita Shafiq, A. P. Cicerone et al. · 0 citations

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