Author

Jun-Qing Hou

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Open access Aug 2026

H2BK5ac is required for the establishment of inflammatory potential in mouse embryonic stem cells following differentiation.

Embryonic stem cells (ESCs) are refractory to inflammatory stimuli but acquire inflammatory competence upon differentiation, yet the underlying mechanisms remain unclear. Here, we report that H2BK5ac regulates the acquisition of inflammatory potential in mouse ESCs during differentiation. H2BK5ac levels increased at th...

Yan Xi, Shuai Pei, Qian-Qian Lou et al. · Cell Reports · 0 citations

Review Open access Jul 2026

Canonical Wnt signaling in the regulation of prostate cancer stem cells: a key driver of castration-resistant prostate cancer and a therapeutic opportunity

Prostate cancer (PCa) is the second leading cause of cancer-related death among men worldwide. Although androgen deprivation therapy (ADT) effectively suppresses tumor growth, most patients eventually progress to castration-resistant prostate cancer (CRPC) and develop metastatic disease. The self-renewal, lineage pla...

Hao-Ze Li, Hong-Tao Xu, Yifan Hou et al. · Journal of Translational Med... · 0 citations