Microbial production of l-arginine is often constrained by tight metabolic regulation and insufficient precursor supply. Here a plasmid-free, non-auxotrophic Escherichia coli strain for high-level production of l-arginine was rationally engineered, based on our previous constructed strain G0 with 12.4 g/L l-arginine pr...
Xin Gao, An-Yi Wu, Zi-Teng Yang et al.· Bioresource Technology· 0 citations
d-Pantothenic acid (D-PA) is an essential precursor of coenzyme A and the acyl carrier protein. Its biosynthesis requires abundant precursors and precise regulation of the multifunctional enzyme, ketopantoate reductase. Here, we engineered Corynebacterium glutamicum for enhanced D-PA production through metabolic engi...
Qing Yang, Bo Zhang, Liang-Gang Huang et al.· ACS Synthetic Biology· 0 citations
This study establishes a robust chassis for sustainable DPA production and provides a generalizable framework for engineering other valuable biochemicals.
Qing Yang, Tao-Shun Zhou, Bo Zhang et al.· Biotechnology and Bioenginee...· 0 citations
A bee ovum-inspired hydrogel that mimics the parasitic wasp egg strategy, firm host adhesion and staged bioactive secretion, is designed, offering a promising approach for refractory diabetic wound therapy through microenvironment-responsive sequential treatment and upstream mitochondrial homeostasis restoration.
Ya-Nan Xue, Ying Lu, Yi-Ran Lin et al.· Materials Today Bio· 0 citations
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