Author

Jun Kang

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Open access Sep 2026

Sonogenetics Nanomedicine Activates the cGAS‐STING Pathway for Immunotherapy of Triple‐Negative Breast Cancer

ABSTRACT Due to pronounced tumor heterogeneity and the lack of effective therapeutic options, triple‐negative breast cancer (TNBC) remains a formidable clinical challenge for the development of effective medicines. Here, we report a HER3‐targeted sonogenetic mechano‐immunomodulatory nanoplatform (HSMIN‐LNP), achieving...

Jun-Ya Song, Yan Liu, Shi-Feng Zhao et al. · Advancement of science · 0 citations

Sep 2026

CD36-Pocket Targeting Induces Metabolic Collapse and Disulfidoptosis for Sonodynamic Immunometabolic Therapy of Liver Cancer.

Obesity-driven lipid accumulation in hepatocellular carcinoma (HCC) establishes a coupled metabolic-immunosuppressive niche that fuels tumor progression and undermines anti-tumor immunity. Through multiplexed immunofluorescence profiling of clinical HCC tissues stratified by visceral adiposity, we explicitly map this l...

Liang Zhang, Meng-Xin He, Yao-Wu Lu et al. · Small · 0 citations