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Author

Jun-Kai Yang

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Open access Oct 2026

Early-life human lymphopoiesis generates a distinct B-cell lineage

We characterize the first wave of human B-lymphopoiesis across gestation (n=42 donors) and identify a developmentally and functionally distinct B-cell lineage that shapes antibody specificity before birth. The earliest lymphoid progenitors engage an evolutionarily conserved genetic program enriched for imprinted genes...

Alexandra F. Nazzari, Krishna Kothari, Jun-Kai Yang et al. · 0 citations

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