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Open access Sep 2026

Elevated blood urea nitrogen-to-albumin ratio is associated with incident sepsis-associated delirium: evidence from a weighted competing-risk analysis in a multicenter cohort study

Background Sepsis-associated delirium (SAD) is a frequent manifestation of acute brain dysfunction in sepsis. Although the blood urea nitrogen-to-albumin ratio (BAR) has been associated with prognosis in critically ill patients, its relationship with incident SAD remains uncertain. We evaluated the association between...

Yun Xia, Jun Jin, Jiang-Tao Deng · 0 citations
Open access Aug 2026

Integrated transcriptomic profiling implicates MAPK14/p38α as a candidate shared molecular target at the sepsis–postoperative delirium interface with computational evidence for a losartan–MAPK14 association

These findings implicate MAPK14/p38α/p38α as a candidate shared molecular target between sepsis and POD and explore a clinically feasible pharmacological candidate linked to the prioritized target.

Weixin Kong, Jing-Xian Xue, Lei Yu et al. · 0 citations

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