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Review Open access Sep 2026

A systematic review and network meta-analysis of first-line EGFR-TKI-based combination strategies for EGFR-mutant non-small cell lung cancer with brain metastases

Brain metastases are common in epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC) and remain clinically challenging despite the improved central nervous system activity of third-generation EGFR tyrosine kinase inhibitors (EGFR-TKIs). Because direct comparisons between active first-line c...

Jia-Yu Ma, Wei-Xin Zhao, Wanjing Guo et al. · 0 citations
Review Open access Aug 2026

Efficacy and safety of antibody-drug conjugates in advanced small cell lung cancer: a systematic review and single-arm meta-analysis of prospective clinical trials

Background Antibody-drug conjugates (ADCs) are being evaluated in advanced small cell lung cancer (SCLC), but the available trials include different targets, constructs, doses, and treatment settings. We aimed to determine the overall range of reported activity and safety while clarifying whether the evidence supports...

Pei-Pei Zhang, Wei-Xin Zhao, Jia-Yu Ma et al. · 0 citations

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