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Open access Jun 2026

Telomere length as a systemic aging-related susceptibility marker for trigeminal neuralgia: Genetic evidence from mendelian randomization.

ObjectiveTo evaluate whether genetically proxied leukocyte telomere length (TL), a systemic marker of biological aging and cumulative cellular stress, is associated with trigeminal neuralgia (TN) risk.BackgroundTN is a severe craniofacial pain disorder classically attributed to neurovascular compression and focal trige...

T. Adegbenro, Jun He, Renato Polimanti et al. · 0 citations
Open access Oct 2026

Biological Aging, Adiposity, and Inflammation in Degenerative Spine Disease: Mendelian Randomization and Longitudinal UK Biobank Analyses.

Leukocyte TL was modestly associated with incident degenerative spine disease and lumbar decompression, but did not show a causal effect, and appears to reflect cumulative biological aging rather than directly drive degenerative spine pathology.

T. Adegbenro, Jun He, Renato Polimanti et al. · 0 citations

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