Author

Junchao Cai

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Open access Oct 2026

PRAME Augments K63‐Linked Ubiquitination and Stabilization of METTL3 to Promote Lung Adenocarcinoma Metastasis

It is demonstrated that the significantly upregulated PRAME in metastatic LUAD directly interacts with the m6A methyltransferase METTL3 and promotes its K63‐linked non‐proteolytic ubiquitination, identifying K63‐linked ubiquitination as a previously unrecognized post‐translational modification of METTL3.

Xia Yang, Xue-Mei Xu, Ya-Xuan Zhang et al. · MedComm · 0 citations

Open access Aug 2026

Selenium Nanoparticles Selectively Target KRAS G13D to Inhibit Colorectal Cancer

ABSTRACT Despite substantial progress in KRAS‐targeted therapies, specific inhibitors of the KRAS G13D mutant remain unavailable. In a retrospective analysis, we found a notable downregulation of glutathione peroxidase 2 (GPX2) in KRAS G13D‐ mutant colorectal cancer (CRC), which correlated with poor outcomes. We hypoth...

Xiao-Ting Liu, Chong Wu, Shi-Yao Song et al. · Advancement of science · 0 citations

Open access Jul 2026

A USP15/KRT17-associated 13-gene prognostic cluster and functional validation in EGFR-mutant lung adenocarcinoma.

A 13-gene prognostic cluster associated with poor survival in EGFR-mutant LUAD is identified and the EGFR-regulated USP15/KRT17 axis is position as a novel framework for patient risk stratification, with potential implications for guiding targeted therapeutic strategies.

Jia-ming Huang, Yi Huang, Qiurong Yuan et al. · Respiratory Research · 0 citations