Author

Juliet K. Knowles

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Open access Sep 2026

A Computational Framework for Myelin as a Regulator of Temporal Integration, Neuronal Excitability, and Synaptic Plasticity

ABSTRACT Myelin regulates neural signaling not only by enabling fast conduction but also by dynamically tuning axonal conduction velocity (CV) and thereby shaping spike timing. While activity‐dependent myelination is thought to optimize neural communication, how changes in myelin translate into altered single‐cell dyna...

Daniel O'Sullivan, Aref Pariz, Daniel Trotter et al. · Glia · 0 citations

Open access Jul 2026

A prospective natural history study protocol for clinical trial readiness in synaptic disorders.

A feasible natural history protocol with prospective data for two complex neurodevelopmental disorders with natural histories that have previously been incompletely characterized is presented, within a regulatory framework that will support the use of these data to expedite clinical trial development.

J. McKee, S. Ruggiero, K. Cunningham et al. · Epilepsia · 0 citations