Author

Julianne N. d’Acunzo

3 papers indexed here

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Open access Oct 2026

Spatiotemporal heterologous vaccination relies on type I interferons at priming to enhance mucosal immunity.

Parenteral vaccines against respiratory viruses poorly block infection and transmission due to suboptimal induction of mucosal immunity. In contrast, hybrid immunity and heterologous-route immunization regimens generate protective mucosal and systemic immunity. Herein, we examine how chronological order in heterologous...

Matthew J. Wiest, Gabriel Laghlali, Julianne d'Acunzo et al. · EMBO Molecular Medicine · 0 citations

Open access Aug 2026

Adjuvanted mucosal vaccination enhances protection and prevents influenza virus transmission in the guinea pig model

Influenza virus infects the respiratory mucosa, highlighting the importance of mucosal immunity for early protection and transmission control. Here, we evaluated whether intranasal (IN) vaccination with recombinant trimeric hemagglutinin protein from A/Michigan/45/2015 (triHA) formulated with a combined mucosal adjuvan...

V. Yan, Seok-Chan Park, Matthew J. Wiest et al. · bioRxiv · 0 citations

Open access Jul 2026

Strategically leveraging Influenza A induced trained immunity to shape immune profiles to subsequent vaccination with heterologous antigens 2309699

It is demonstrated that vaccination through different routes (mucosal vs. systemic) differentially harnesses trained immune responses established by prior viral respiratory infection and alters the local inflammatory cell composition and subsequently alters the Th and mucosal antibody response induced by immunization.

Matthew J. Wiest, James R. Baker, Chun Chen et al. · Journal of Immunology · 0 citations