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Author

Julia Orzelska

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Review Open access Sep 2026

Refining the TCGA Framework: The Pivotal Role of Targeted Next-Generation Sequencing in Resolving Diagnostic Ambiguities in Endometrial Cancer—Systematic Review

The classification of endometrial cancer based on histological examination often fails to accurately predict treatment outcomes for patients. The Cancer Genome Atlas (TCGA) has proposed a new molecular model that more accurately identifies the tumour subtype, enabling more precise treatment. However, its implementation...

Natalia Gierulska, Julia Orzelska, Katarzyna Lachowska et al. · 0 citations
Review Open access Sep 2026

Prognostic and therapeutic implications of BRCA1 and BRCA2 mutations in ovarian cancer

BRCA1/2 mutation status is a key biomarker in the management of ovarian cancer, supporting personalized treatment strategies and improving patient outcomes, and emerging mechanisms of resistance to PARP inhibitors remain a significant therapeutic challenge.

Weronika Pawul, Paulina Opoka, Agata Dusza et al. · 0 citations

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