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Author

Julia Grzybowska

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Open access Aug 2026

mTORC1 inhibition upregulates CD20 and enhances anti-CD20 antibody efficacy in B-cell precursor acute lymphoblastic leukemia.

It is demonstrated that overexpression of wild-type IKZF1, a tumor suppressor frequently mutated in high-risk BCP-ALL, upregulates CD20 and promotes leukemic B cell maturation, and the use of mTORC1 inhibitors to sensitize BCP-ALL cells to CD20-directed immunotherapies is supported.

Agnieszka Dąbkowska, Martyna Janowska, Agata Pastorczak et al. · 0 citations

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