Open access
Aug 2026
Loss of cohesin subunit Stag1 in zebrafish limits cell cycle progression and is compensated by altered BMP signalling and metabolic pathways
It is shown that, unlike mammals, zebrafish can tolerate complete loss of Stag1 from embryogenesis through to adulthood, and it is proposed that modulation of growth and signalling pathways compensates for the absence of Stag1, allowing embryonic development to proceed correctly.
Dylan M. Lynch, Anastasia A. Labudina, Sarada Ketharnathan et al.
· bioRxiv · 0 citations