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Author

Juheb Akhter

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Open access Sep 2026

Human skin fibrosis with iPSC-derived organoids reveals RUNX2-mediated fibroblast reprogramming

Fibrotic skin diseases are characterized by persistent fibroblast activation and extracellular matrix remodeling, yet the mechanisms governing fibroblast state transitions remain incompletely understood. Here, we established a human iPSC-derived skin organoid model of fibrosis through chronic TGF-β stimulation. Single-...

J. Khan, S. Mehmood, Fuad Al Abir et al. · 0 citations

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