Abstract Background Renal cell carcinoma (RCC) is characterized by a highly immunosuppressive tumor microenvironment enriched in tumor-associated macrophages (TAMs) and regulatory T cells (Tregs), both of which correlate with poor clinical outcomes. TAMs in RCC commonly exhibit an immunosuppressive phenotype, marked by...
Giuliana P. Mognol, E. Wang, William Harris et al.· The Oncologist· 0 citations
Current therapeutic strategies targeting TAMs are reviewed, including approaches directed against macrophage-associated receptors, signaling pathways, and epigenetic and metabolic regulators and emerging TAM-targeted therapeutic modalities are discussed, highlighting their potential to enhance antitumor immunity and im...
Shweta S. Joshi, Judith A. Varner· Trends in Cancer· 0 citations
It is shown that KRASG12D mutations in lung epithelium drive proliferation of resident, embryonically-derived alveolar macrophages, which then promote tumor cell proliferation and protection from ferroptosis, leading to tumor progression.
Jaroslav Zak, Hui Chen, Erpei Wang et al.· bioRxiv· 0 citations
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