ABSTRACT Sepsis is a systemic inflammatory response syndrome triggered by an uncontrolled host response to infection, which causes acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Baicalein (Bai) is one of the major active components of Scutellariae Radix for treating pulmonary diseases. However,...
This work uncovered Uhrf1‐dependent PKM2 ubiquitination/degradation as a previously unrecognized therapeutic axis for IBD, while positioning EPT as a molecular glue capable of targeting the Uhrf1–PKM2 complex.
Juan Zhang, Xin-rong Xu, Hui-lin Zhang et al.· Advancement of science· 0 citations
PBK/TOPK is a serine/threonine kinase belonging to the mitogen-activated protein kinase kinase family, involved in the regulation of cell survival, proliferation, growth, apoptosis, and inflammation response. It is overexpressed in various malignant tumors and participates in chromosome condensation, mitotic progressio...
