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Sep 2026

YBX3 Promotes Ischemia-Reperfusion Injury by Enhancing Microglial Glycolysis via PKM2 Stabilization and mTOR-HIF-1α Pathway Activation.

Stroke remains one of the leading causes of death and long-term disability worldwide, with neuroinflammation and metabolic dysfunction playing central roles in its pathogenesis. In this study, we investigated the function of Y-box binding protein 3 (YBX3) in ischemic stroke, with particular focus on its regulation of g...

Zhao-Wei Feng, Pei-Pei Qin, Hua Ni et al. · 0 citations
Open access Sep 2026

A palmitoylation-associated three-gene signature predicts prognosis, immune features, and drug sensitivity in gastric cancer: functional validation of CTHRC1

Gastric cancer (GC) is a heterogeneous malignancy that requires improved molecular tools for prognostic stratification. Protein palmitoylation regulates membrane localization and signaling, but the clinical relevance of palmitoylation-related genes (PRGs) in GC remains unclear. Gene Expression Omnibus, The C...

Hong-Mei Sheng, Xue-Jun Li, Chen Zhang et al. · 0 citations
Open access Sep 2026

Palmitoylation-related lncRNAs link molecular signaling, immune remodeling, and tumor progression in glioma: prognostic modeling and functional validation of LYRM4-AS1

Background Glioma is a molecularly heterogeneous tumor of the central nervous system with variable clinical behavior, immune contexture, and therapeutic response. Palmitoylation is a reversible lipid modification that regulates membrane localization, synaptic signaling, inflammatory pathways, and oncogenic signaling; h...

Juan Xu, Chen Zhang, L. Pu et al. · 0 citations

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