Epigenetic regulation may underlie asymmetric allelic expression of many genes during development and disease pathogenesis. Allele-specific epigenetic modification could provide an efficient therapy for dominant genetic diseases due to heterozygous mutations. We developed an allele-specific epigenetic editing method ("...
How differences in brain cell composition help define cortical folds are uncovered and a link between microscopic cellular organization and large-scale brain networks in primates is revealed.
Ying-Guang Bai, Tao Song, He Wang et al.· Nature Communications· 0 citations
Fullscope-seq resolved hundreds of major isoform switches across distinct brain regions and identified DTUs between superficial and deep cortical layers and showed substantial enrichment for neuropsychiatric disorder-associated genes.
Hengxin Liu, Yanhong Hong, Y. Zhang et al.· Nature Methods· 0 citations
It is shown that TLE patients have structural changes in two brain regions, the posterior cingulate cortex and dorsolateral prefrontal cortex, linked to slower processing speed and poorer working memory, which helps explain how microscopic gene patterns may contribute to large‐scale brain changes and cognitive difficul...
Yaping Dong, Shuai Wang, Jingjie Luo et al.· Epilepsia Open· 0 citations
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