Review
Open access
Aug 2026
Functional genomics–guided design of CAR-T and CAR-NK therapies in hematological malignancies: aligning cellular engineering with immune escape and microenvironmental resistance
Future CAR-T and CAR-NK development should link each modification to a measurable resistance mechanism, a feasible biomarker, and a clinically testable benefit, before resistance-matched cellular immunotherapy can be broadly integrated into clinical practice.
Shi-Qi Cai, Yang Tan, Qian Yang et al.
· Frontiers in Genome Editing · 0 citations