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Author

Juyong Lee

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Open access Oct 2026

PREpiBind: Protein Representation-integrated Epitope–MHC Class II Binding Prediction

Motivation Accurate peptide–MHC class II (pMHC-II) binding prediction is complicated by MHC polymorphism and context-dependent peptide recognition. Protein representations are usually evaluated in different pipelines, obscuring their contribution to predictive performance. Results We present PREpiBind, a joint-attentio...

D.-K. Jang, Dongwoo Kim, Untaek Hwang et al. · 0 citations
Open access Aug 2026

LEN-Seek: Fast and scalable ligand binding-site similarity search in the latent space of an SE(3)-invariant graph VAE

Motivation Ligand binding-site similarity search is a crucial step in drug discovery that reduces the conformational search space for docking and other downstream tasks by comparing a target protein against experimentally identified binding sites. Existing methods rely on either direct structural alignment or lossy com...

Kyunghwan Yeo, Dongwoo Kim, Jaemin Sim et al. · 0 citations

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