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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Ju-Peng Yuan

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Open access Sep 2026

ITGA5 promotes homologous recombination mediated radioresistance in esophageal squamous cell carcinoma by upregulating RAD51AP1 expression.

Radiotherapy resistance represents a critical barrier to successful treatment of esophageal squamous cell carcinoma (ESCC), driving tumor recurrence and poor patient survival. We identify constitutive overexpression of integrin α5 (ITGA5) as a key molecular determinant of ESCC radioresistance. Clinically, elevated ITGA...

Xin-Yi Huang, Jia-Yi Liu, Jiao Ren et al. · 0 citations
Open access Jul 2026

TFAP2A enhances radioresistance of non-small cell lung cancer by transcriptionally activating BRCA1

Radioresistance remains a major obstacle in the treatment of non-small cell lung cancer (NSCLC). Transcription factor AP-2α (TFAP2A) has been implicated in tumor progression, but its role in NSCLC radioresistance and translational therapeutic relevance remain unclear. Bioinformatics analyses of TCGA and GEO datasets we...

Jiachun Ma, Fei Wang, Jingxin Zhang et al. · 0 citations

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