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Author

Josie Coulthard

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Open access Aug 2026

Targeting epigenetic regulators induces transcription-replication conflicts to overcome ATR inhibitor resistance

Abstract Many cancer cells exhibit elevated replication stress and are highly dependent on ataxia telangiectasia and Rad3-related (ATR) kinase activity to maintain genomic stability and survival. While ATR inhibitors (ATRi) have great promise as therapeutic agents, intrinsic or acquired resistance will likely be a sign...

Samah W. Awwad, Holly Barber, Josie Coulthard et al. · 0 citations

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