Josephine Marie Boldt Lundby

Population-specific transcriptional-state remodeling of cortical and hypothalamic neurons in Alzheimer’s disease

In human Alzheimer’s disease, remodeling was strongest in several deep-layer and RORB-positive excitatory populations independently associated with vulnerability, and an independently defined human depletion-associated neuronal identity instead overlapped other synaptic and calcium-signaling components of the same broa...