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Joseph Kim

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Archetype analysis of multiplexed antibody imaging reveals interpretable morphological programs in optical pooled screens

High-content imaging-based screens with small molecule or genetic perturbations rely on rich optical phenotypes, yet how distinct subcellular markers contribute complementary biological information remains unclear. Here, we introduce CellMAPP, a multiplexed organelle imaging platform that uses optical pooled screens wi...

Paula Coelho, Ana Carolina Leote, He-Ming Yao et al. · 0 citations
Open access Jul 2026

Spatial atlas of the human brain vasculature reveals specialized cell ensembles.

A comprehensive cerebrovascular cell atlas encompassing 314,535 transcriptomes is constructed that captures the arteriovenous axis and defines consensus cell states and identifies ensemble-specific susceptibilities and candidate therapeutic targets across neurological diseases, including small vessel disease and stroke...

Jerry C. Wang, Damian A Sanchez, Santhosh Arul et al. · 1 citation

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