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Author

José E. León-Rojas

5 papers indexed here

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Open access Sep 2026

Perceived loneliness, problematic pornography use, and psychological distress in Ecuadorian university students: a correlational path analysis

Introduction Loneliness is increasingly recognized as a transdiagnostic vulnerability among university students, yet the behavioral correlates associated with psychological distress remain insufficiently understood. This study examined the statistical indirect association between perceived loneliness and psychological...

M. Morales-Cevallos, Gonzalo López-Barranco, Daniel Oleas et al. · 0 citations
Review Open access Aug 2026

Exercise Loading Strategies for Patellar Tendinopathy: A Systematic Review and Meta-Analysis of Clinical Outcomes

Background: Patellar tendinopathy is a persistent load-related condition in athletes, and exercise is recommended as first-line care; however, the comparative value of specific tendon-loading prescriptions remains uncertain. This systematic review aimed to synthesize exercise-based interventions for adults with patella...

Alejandro Bruna-Mejías, Rodrigo Cañas-Jamett, J. Valenzuela-Fuenzalida et al. · 0 citations
Review Open access Aug 2026

Vagus Nerve Modulation of the Gut-Brain Axis: Implications for Mental Health and Cognitive Function.

The vagus nerve constitutes a core bidirectional pathway linking the central nervous system with peripheral organs and plays a fundamental role in gut-brain communication. Beyond its classical autonomic functions, accumulating evidence positions vagal signaling as a candidate integrative mechanism through which viscera...

Diana Álvarez-Mejía, Guido Mascialino, José E. León-Rojas · 0 citations
Review Open access Aug 2026

Early Childhood Movement- and Arts-Based Experiences and Executive Functions: A Systematic Review and Meta-Analysis

Highlights What are the main findings? Across 15 Study IDs and 29 model-ready effects, average benefits were observed for inhibition, working memory and cognitive flexibility, but all prediction intervals crossed the null, and GRADE certainty was low. The quantitative core comprised 12 primarily structured programmes a...

Gustavo Vega-Fernandez, J. Valenzuela-Fuenzalida, Yasna Jeria-Pizarro et al. · 0 citations
Review Open access Sep 2026

Next-Generation Liposomal and Nanoparticle-Based Systems for Glioblastoma: Molecular Targeting Strategies to Overcome the Blood–Brain Barrier

Glioblastoma (GBM) remains one of the most lethal and intractable central nervous system malignancies, characterized by aggressive cellular proliferation, profound hypoxia, and an immunosuppressive microenvironment. The primary pharmacokinetic obstacle for systemic interventions is the blood–brain barrier (BBB), which...

Joaquin Fiallo Arroyo, Bernardo Castellón, José E. León-Rojas · 0 citations

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