Author

Jörn Stitz

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Open access Sep 2026

Transposon Vectors Enable Accelerated Development of Cellular Assay Platforms for the Identification and Characterization of Anti-Viral Small-Molecule Cell-Entry Inhibitors and Neutralizing Antibodies

Background/Objectives: Screening for neutralizing antibodies (nAbs) or antiviral small-molecule inhibitors (SMIs) using live virus is laborious and often confined to higher biosafety levels, thus restricting accessibility. The use of murine leukemia virus (MLV)-derived pseudotype vector particles displaying spike or en...

Mona Pißarreck, Kristina Katsoutas, Celina Lea Kinder et al. · Biomedicines · 0 citations

Open access Aug 2026

High-titer human packaging cells producing γ-retroviral vectors pseudotyped with engineered baboon endogenous retrovirus (BaEV) envelope proteins

This proof-of-concept study underlines the utility of the Env variant BaEV-TR for the establishment of stable pseudotype VPCLs and the utilization of HT1080 cells as an alternative to frequently used 293T host cells.

Angelina Hallik, Mona Pißarreck, Mats Jürgen Grummel et al. · Frontiers in Molecular Medic... · 0 citations