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Author

Jorge Ruiz-Orera

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Sep 2026

The molecular landscape of hypertrophic cardiomyopathy across disease stages and genotypes.

Unsupervised and supervised machine learning approaches distinguished HCM from dilated cardiomyopathy and accurately predicted genotype status in early-stage HCM from cell type-resolved transcriptional profiles, revealing widespread genotype-driven remodeling.

E. Adami, Yuri Kim, Sean L. Zheng et al. · 1 citation
Open access Sep 2026

Nx3 Is a Z-Disk Structural and Signaling Hub That Is Reduced in Heart Failure.

BACKGROUND Nx3 (novex-3) is an exceptionally small isoform of the giant protein titin, whose structural and functional roles within the sarcomere remain poorly understood. METHODS AND RESULTS We used a comprehensive, multimodal approach to define the key properties of Nx3 in healthy and failing hearts, including its...

W. Linke, Lisa Kümper, A. Fomin et al. · 0 citations

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