Author

Jorge A. R. Salvador

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Review Open access Oct 2026

Highlights in Cysteine Protease Inhibitors as Antiparasitic Agents Against Trypanosomatids

Trypanosoma cruzi, Trypanosoma brucei and Leishmania spp. are the causative agents of Chagas disease, human African trypanosomiasis, and leishmaniasis, respectively. These three neglected tropical diseases affect millions of individuals globally, and current therapeutic options remain severely limited. The major cystei...

Beatriz M. R. Querido, M. C. Sousa, Jorge A. R. Salvador · International Journal of Mol... · 0 citations

Open access Jul 2026

Synthesis and biological evaluation of oridonin derivatives as antiproliferative agents against colorectal cancer

Mechanistic studies and structure–activity relationship analysis identify compound 11b as a valuable scaffold for further development of novel anticancer agents targeting CRC, and reduce intracellular ROS levels and attenuated mTOR signaling.

Pedro J. M. Sobral, Rita Oliveira, Silvia Marín et al. · RSC Medicinal Chemistry · 0 citations