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Sponsored Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt

Author

Jordan de Jesus Silva

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2 papers indexed here

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Sep 2026

Discovery of Novel Oral Covalent Inhibitors Targeting Active GTP-Bound KRASG12C with Potent Antitumor Activity

Current KRASG12C inhibitors mainly target the inactive GDP-bound state, but clinical efficacy is limited, and resistance mechanisms have been identified. We disclose novel covalent inhibitors that selectively target the active GTP-bound KRASG12C. Starting from a high-throughput screen, we identified a keto-indolizine...

Juan del Pozo, Elisabeth T. Hennessy, Patrick Schoepf et al. · 0 citations
Sep 2026

SuFEx Cyclization Enables DNA-Encoded Macrocyclic Peptide Libraries for Drug Discovery

Rapid, aqueous macrocyclization strategies that proceed in high conversion are valuable for ultralarge macrocyclic peptide (MP) library synthesis via display and DNA-encoded library (DEL) technology. Here we report an on-DNA macrocyclization based on sulfur(VI) fluoride exchange (SuFEx) that unites above features. Th...

Tian-Xiong Mi, Li-Jun Fan, Amber Hackler et al. · 0 citations

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