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Sponsored AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI

Author

Joon-Yong An

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Open access Sep 2026

AnnFlux: object-conditioned neural stochastic differential equations for single-cell perturbation dynamics

This framework maps perturbation-driven cell-state evolution as continuous trajectories and represents unseen perturbations using prior-knowledge embeddings and improves distributional fidelity and predicts responses to held-out perturbation combinations.

Hee-Sun Choi, Gaeun Byeon, Hayoon Park et al. · 0 citations
#generative ai Review Open access Sep 2026

Toward AI Virtual Cells for Hepatology: Representation, Generation, Dynamics, and Intervention in Single-Cell Models.

``Single-cell and spatial atlases describe the healthy and diseased liver at high resolution, including lobular hepatocyte zonation, fibrotic macrophage-stellate niches, cholangiocyte reactions, immune remodeling, and hepatocellular carcinoma ecosystems. These maps show where cell states occur but do not, by themselves...

Youngseok Choi, I. Koh, Murim Choi et al. · 0 citations
Review Open access Jul 2026

Cancer therapy resistance converges on immune evasion: a unified framework from immunotherapy to targeted, endocrine, and DNA repair pathways

It is argued that resistance to targeted therapies, endocrine therapies, and PARP inhibitors should not be treated as a problem separate from immunotherapy resistance, but rather, these resistant states often converge on the same three axes that govern immunotherapy resistance (immune visibility, access, and effector f...

Ha-Eun Jeong, Heesun Choi, W. Lim et al. · 0 citations

Molecules and Cells

Genotype-dependent neurodevelopmental phenotypes associated with reduced USP15 dosage are characterized and a human neural framework for investigating ASD-relevant developmental mechanisms in the context of a rare ubiquitin-pathway variant is provided.

Tae-Hwan Park, I. Koh, S. Sung et al. · 0 citations
Open access Aug 2026

megaMine: a scalable, rule-based framework for mining gene-cancer-drug evidence from biomedical literature

The rapid expansion of the oncology literature has outpaced manual curation of clinically relevant gene-cancer-drug associations and oncogenic driver evidence. Existing automated approaches often lack transparency or are difficult to scale across heterogeneous data sources. To address this gap, we developed megaMine, a...

Muhammad Junaid, K. Prazanowska, Ha-Eun Jeong et al. · 0 citations
Open access Jul 2026

USP15 mutation associated with autism spectrum disorder alters progenitor fate and neuronal maturation in human brain organoids.

De novo variants in the ubiquitin-proteasome pathway are linked to autism spectrum disorder (ASD), yet their functional impact on neurodevelopment remains poorly understood. We investigated USP15, a deubiquitinating enzyme with rare damaging variants identified in individuals with ASD, using isogenic human iPSC-derived...

Tae-Hwan Park, I. Koh, Seoyoung Sung et al. · 0 citations

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