Harnessing the Folding of Antitumor Peptides for Controlled Carrier-Free Drug Delivery.
An antitumor peptide-based delivery platform in which both termini of a stapled p53 α-helix are linked via a disulfide bond, thereby repurposing nonpolar residues originally involved in target protein (hDM2) binding as a hydrophobic block that drives co-assembly with doxorubicin.
Jae Yun Lee, Moo Chang Park, Sung-Chan Choi et al.
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