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Jong Shin

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Open access Aug 2026

Plaque-associated oligodendrocyte proteostatic failure underlies myelin loss in Alzheimer’s disease

Findings identify plaque-associated oligodendrocyte proteostatic failure as a candidate mechanism of myelin loss and a potential therapeutic pathway in AD and restores MBP protein levels and improves compact myelin ultrastructure in AD organoids.

Jong Shin, Nandita Joshi, Brendan F. Miller et al. · 0 citations

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