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Author

Jonathan Maelfait

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Review Open access Sep 2026

ZBP1 evolution and antagonism by large DNA viruses.

ZBP1 is a nucleic acid receptor that restricts virus infection by activating an inflammatory gene response and by inducing host cell death. Left-handed Z-form nucleic acids accumulating in infected cells activate ZBP1 by binding to its N-terminal Zα domains. Signal transduction relies on the presence of RIP homotypic i...

Mamadou Amadou Diallo, Jonathan Maelfait · 0 citations

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