Robustness of Randomized Trials Comparing Operative and Non-Operative Management of Acute Uncomplicated Appendicitis: A Fragility Analysis.
BackgroundThe fragility index (FI) is a statistical evaluation of the robustness of randomized controlled trials (RCTs) and quantifies how many patient outcomes would need to change to alter statistical significance. A FI of ≤3 is considered a fragile study. This study assessed the fragility of RCTs comparing non-opera...