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Jonathan D. Winkelman

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#protein folding Open access Oct 2026

Archaea are more hospitable hosts for mobile inteins than bacteria

ABSTRACT Intervening proteins, or inteins, are mobile genetic elements characterized by their ability to rearrange peptide bonds through a post-translational, self-splicing reaction. Here, we expand the scope of a prior investigation to reexamine the distribution of inteins across archaea and bacteria. This update repr...

Tia M. Ariagno, Jonathan D. Winkelman, Marlene Belfort et al. · Microbiology spectrum · 0 citations

Open access Jul 2026

Functional analysis of natural variation in the RNA-binding protein CsrA across the bacterial domain predicts regulatory activity

Swarm-seq is established as a powerful platform for characterizing CsrA homologs from genetically intractable or unculturable bacteria and the potential for machine learning-guided discovery of functional regulatory proteins is demonstrated, providing insights into post-transcriptional regulatory network evolution.

Jared T. Winkelman, Ethan Yarberry, Georgia Fanouraki et al. · Nucleic Acids Research · 0 citations