Open access
Aug 2026
Reprogramming lineage-traced Müller glia for robust proliferation and neurogenesis in adult mammalian retinas.
It is demonstrated that activation of FGF2/MAPK signaling, following AAV-mediated gene transfer of Ascl1, effectively stimulates lineage-traced MG to undergo robust cell-cycle re-entry in adult mice, independent of neurotoxic injury.
Ye Xie, Ying Xin, Thomas E. Zapadka et al.
· Cell Reports · 0 citations