Author

Jonathan A. Stefely

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Open access Oct 2026

Comparative analysis of mitochondrial proteomes across the tree of life.

Mitochondria arose from the endosymbiosis of a bacterium with an archaea-related host cell about 2 billion years ago. To understand their origins and evolution, we compared experimentally defined mitoproteomes from the MitoCarta Tree of Life project. Across eight organisms, we identified 8,619 distinct mitochondrial pr...

Michael Z. Chen, Jonathan A. Stefely, Eric G. Bardon et al. · Cell · 9 citations

Open access Oct 2026

Conserved and divergent mitochondrial assemblies in kinetoplastid parasites

SUMMARY The mitochondrial proteomes of Leishmania tarentolae and Trypanosoma brucei contain ~1,700 proteins, most of which lack homologs in higher eukaryotes. Here, we integrate complexome profiling and cryo-electron microscopy to define conserved and lineage-specific macromolecular assemblies that support mitochondria...

Md Solayman, Yi-Ting Liao, Sarah E. Calvo et al. · Molecules and Cells · 2 citations