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Jon Reed

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Open access Aug 2026

Directed Evolution in Codon Space

A language-model-guided framework that iteratively refined industry-optimized coding sequences of clinical-stage therapeutics through synonymous exploration of codon space establishes directed evolution as a practical strategy to improve biologic expression, a key manufacturing bottleneck, without altering protein sequence.

James Heuschkel, Laura Kingsley, Jon Reed et al. · 0 citations

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