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Johnathan Labbadia

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Review Open access Oct 2026

More than the ‘master regulator of cytosolic proteostasis’: new roles for HSF1 in promoting tissue health

Abstract Maintaining protein homeostasis (proteostasis) is crucial for long-term tissue health. This requires the action of stress response pathways and protein quality control mechanisms that act within or across different sub-cellular compartments to preserve proteome integrity. Within the cytosol/nucleus, the loss o...

Johnathan Labbadia · 0 citations
Open access Jul 2026

Spatial ecology of breast cancer reveals co-evolution of proliferative and dormant niches.

A G0 persister-like state with reduced copy number alteration burden and hallmarks of dormancy is uncovered, characterised by transcriptional reprogramming of stress response pathways and increased epithelial-mesenchymal plasticity.

Cenk Celik, William A. Weston, Thais de Moraes-Lacerda et al. · 1 citation

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