Author

John R. Yates

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Open access Jul 2026

Quantitation of Spatial Proteoforms in Alzheimer’s Disease

Findings establish spatial proteoforms as essential units of pathogenic analysis and reveal disease-relevant signals invisible to bulk tissue approaches in Alzheimer's disease.

Daniel B. McClatchy, Natalie P. Turner, John R. Yates · bioRxiv · 0 citations

Open access Jul 2026

Lysosomal permeabilization by Group A Streptococcus releases proteins into the macrophage cytosol 2256825

Unexpectedly, cytosolic extracts of both WT- and α”SLO-infected macrophages contained all histone proteins, suggesting that nucleosomal complexes are released into the cytosol during GAS infection.

Cheryl Y. M. Okumura, A. Quezada, Kevin Lord et al. · Journal of Immunology · 0 citations