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Author

John Orban

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Open access Aug 2026

A Conserved Flexible N-Terminal Domain Tunes the Calcium Sensitivity of Sorcin by Stabilizing Its Active Conformation

The NTD is established as a critical regulator that enhances Ca2+ responsiveness by shifting Sorcin’s conformational equilibrium toward the active state and suggest that flexible N-terminal extensions regulate signaling within the penta-EF-hand protein family.

Qiushi Ye, Angela Wu, K. Carillo et al. · 0 citations
Open access Aug 2026

Benchmarking Deep Learning Predictions of Mutation-Induced Fold Switching

A systematic NMR-characterized dataset of mutants of the GA/GB model fold-switching system is presented and it is found that this benchmark revealed variable and position-dependent performance across methods, with certain AlphaFold2-based algorithms able to predict mutant effects at individual sites, indicating some un...

Nathaniel R. Felbinger, K. Carillo, Yihong Chen et al. · 0 citations

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