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Author

John L. Rubinstein

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Aug 2026

5-Carboxamide-Substituted Barbituric Acids: Promising Scaffolds for Drug Development against Mycobacterium tuberculosis.

The continued spread of drug-resistant Mycobacterium tuberculosis (Mtb) necessitates the development of new chemotypes with novel modes of action. Here, we report 5-carboxamide-substituted barbituric acid as a promising scaffold for developing new drugs against Mtb. Fenoxacrim, the initial hit compound identified throu...

Henok A. Sahile, B. Awasthi, Jonas E. Olsen et al. · 0 citations
Open access Aug 2026

The dynamic and heterogeneous structure of the non-canonical inflammasome.

The stoichiometry of the non-canonical inflammasome is determined showing that it is heterogeneous, comprised of three major complexes with different numbers of LPS and caspase molecules, and NMR results presented establish that the protease domain of caspase-11 is monomeric in isolation.

Alexander I. M. Sever, James M. Aramini, Jeffrey P. Bonin et al. · 0 citations

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