Author

Joel T. Haas

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Open access Aug 2026

Hepatic stellate cell FXR signaling regulates context-dependent functions in liver homeostasis and fibrosis

Nuclear bile acid (BA) signaling plays a central role in liver homeostasis and represents a major therapeutic axis in fibrotic liver diseases. The farnesoid X receptor (FXR), a master nuclear effector of BA signaling, is expressed in several liver-resident cell types, suggesting that it may regulate distinct biological...

Manjula Vinod, F. P. Zummo, Céline Gheeraert et al. · bioRxiv · 0 citations

Open access Aug 2026

The Circadian Clock controls Hepatic Inflammation in MASLD.

BACKGROUND & AIMS The circadian clock dictates time-of-day dependent gene, protein expression, and metabolite levels to ensure liver homeostasis. Circadian misalignment is implicated in the development of various metabolic disorders, but its contribution to the progression of Metabolic dysfunction-Associated Steatotic...

A. Hebras, Marie Bicharel-Leconte, S. Delhaye et al. · JHEP Reports · 0 citations

Open access Aug 2026

PLCG2 downregulation impairs synaptic function and increases Alzheimer’s disease hallmarks in neuronal cultures

It is demonstrated that downregulation of PLCG2, primarily in neurons, impairs synaptic function and elevates amyloid-β levels and Tau protein phosphorylation in neurons.

Audrey Coulon, F. Rabiller, M. Takalo et al. · Nature Genetics · 0 citations