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Author

Joel M. J. Tan

2 papers indexed here

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Open access Aug 2026

Listeria promotes systemic infection by targeting the host deubiquitinase CYLD

Listeria monocytogenes (Lm) is an intracellular pathogen that can cause life-threatening systemic infections. Internalin C (InlC) is a secreted factor required for full Lm virulence in systemic models of infection by mechanisms that remain unclear. Here, we show that InlC binds to CYLD, a host deubiquitinase and regula...

Dustin A. Ammendolia, Cara J. Ellison, Yue-Lin Zheng et al. · 0 citations
Open access Sep 2026

Structure and operating principles of a monkeypox virus replisome

Poxviruses are double-stranded DNA viruses with large genomes. Among them, monkeypox virus (MPXV) has been responsible for two recent public health emergencies as declared by the World Health Organization1. The MPXV polymerase comprises three subunits—a catalytic subunit (F8) and a heterodimeric processivity factor (A2...

Zi-Shuo Yu, Pradeep Sathyanarayana, Joel M. J. Tan et al. · 0 citations

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