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Author

J. Pérez-Schindler

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3 papers indexed here

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Open access Sep 2026

Transcriptional and epigenomic analysis of insulin sensitivity in human adipocytes.

This work isolated adipocytes from subjects with and without insulin resistance and subjected them to transcriptional and epigenomic profiling, allowing it to identify genes, cis-regulatory elements, and pathways that associate with insulin resistance in this critical cell type.

Qian-Bin Zhang, Audrey Zhou, A. Maynard et al. · 0 citations
Open access Aug 2026

Metabolic disease-relevant stimuli unmask context-dependent genetic regulation of cardiometabolic loci in human adipocytes

This study establishes large-scale adipocyte cell villages as a powerful and generalizable framework to map the context-dependent regulatory architecture of cardiometabolic disease and provides a resource linking human genetic variation to adipocyte cellular programs.

Yi Huang, Joaquin Perez-Schindler, Sanchari Datta et al. · 0 citations
Open access Aug 2026

Scalable context-dependent single-cell eQTL mapping reveals disease-relevant regulatory variation beyond static models

In adipose-derived mesenchymal stem cells exposed to metabolic stimulations, CASTIE increased eGene discovery by 36-92% across cell populations and identified stimulation-dependent regulatory effects at metabolic trait loci, revealing disease-relevant regulatory variation beyond static eQTL mapping.

Yijia Christiana Liu, A. Cuomo, Yi Huang et al. · 0 citations

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