João Paulo Lima Santos

White matter microstructure mediates the link between rest-activity rhythm instability and mania symptoms in individuals at risk for bipolar disorder.

Adolescence and young adulthood are critical periods for the emergence of bipolar disorder (BD). Instability in sleep and rest-activity rhythms is associated with elevated risk for BD, yet little is known about the neural correlates of this vulnerability. White matter organization in fronto-limbic pathways, which suppo...